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投稿时间：2023-12-08 网络发布日期：2024-01-20
投稿时间：2023-12-08 网络发布日期：2024-01-20
中文摘要: 肥大细胞（mast cells）是一种先天免疫细胞，长期以来一直被认为与过敏性和自身免疫疾病的发病机制有关。然而近年来不少研究发现，肥大细胞在肿瘤的发生发展、转移、浸润和血管生成中起着不可或缺的作用，为肿瘤的诊断及免疫治疗提供了新思路。肥大细胞一旦浸润实体瘤，就被称为肿瘤相关肥大细胞（TAMCs），是肿瘤组织中极受争议的免疫细胞之一，具有显著的异质性。鉴于肥大细胞在炎症和免疫系统中的重要作用，本文对肥大细胞在实体肿瘤发生发展中的作用机制以及与血管和淋巴管生成的关系作一综述，旨在加深对肥大细胞与肿瘤关系的认识。
Abstract:Mast cells are a type of innate immune cells, and have long been considered to be related to the pathogenesis of allergic and autoimmune diseases. However, in recent years, a number of studies have found that mast cells play an indispensable role in tumor development, metastasis, infiltration and angiogenesis, providing new ideas for tumor diagnosis and immunotherapy. Once mast cells have infiltrated solid tumors, they are known as tumor-associated mast cells (TAMCs) and are one of the most controversial immune cells in tumor tissues with remarkable heterogeneity. In view of the important role of mast cells in inflammation and the immune system, this paper reviews the mechanisms of mast cells in solid tumor development and their relationship with angiogenesis and lymphangiogenesis, aiming to deepen the understanding of the relationship between mast cells and tumors.
keywords: Mast cells Tumor-associated mast cells Solid tumors Tumor micro-environment Angiogenesis Lymphangiogenesis Tumor promotion Tumor suppression
文章编号： 中图分类号：R730.3 文献标志码：A
基金项目:国家自然科学基金（编号：82273422）；南通市社会民生科技计划项目（MS2023067）
附件
| Author Name | Affiliation |
| LUO Yang*, ZHANG Qing, ZHANG Shu, ZHANG Jianguo, LIU Yifei | *Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China |
引用文本：
骆洋,张青,张曙,等.肥大细胞在实体瘤中的作用及机制[J].中国临床研究,2024,37(1):6-11.
骆洋,张青,张曙,等.肥大细胞在实体瘤中的作用及机制[J].中国临床研究,2024,37(1):6-11.