Abstract:Objective To explore whether oral sodium bicarbonate tablets combined with hydration therapy during the perioperative period of coronary angiography in patients with coronary heart disease (CHD) and mild to moderate renal insufficiency have a preventive effect on contrast induced nephropathy (CIN). Methods A total of 100 patients with CHD and mild to moderate renal insufficiency admitted to Beijing Jingmei Group General Hospital from June 2020 to December 2022 were selected. They were randomly divided into two groups, the experimental group（n=46） received hydration therapy combined with oral sodium bicarbonate tablets during the perioperative period, and the control group(n=54) received hydration therapy alone. The hydration rate in both groups was 1 mL/(kg·min). The incidence of CIN was compared between the two groups. Results Both groups of patients successfully completed the surgery, and no serious events such as emergency hemodialysis, acute myocardial infarction, or acute heart failure occurred during the perioperative period. There were no statistically significant differences in gender, age, preoperative creatinine, diabetes, or contrast agent dose between two groups (P＞0.05). In the experimental group, none of the 46 patients developed CIN, while in the control group, 8 out of 54 patients developed CIN (incidence rate of 14.8%). The difference between the two groups was statistically significant (χ2=5.531，P＜0.05). Conclusion Perioperative administration of sodium bicarbonate tablets combined with hydration therapy in CHD patients with coronary angiography has a protective effect on renal function and can reduce the occurrence of CIN.