Abstract:Objective To explore the application and effect of multi-disciplinary team (MDT) combined with case-based learning (CBL) teaching model in clinical teaching of head and neck oncology. Methods A total of 33 resident physicians who participated in the training in the Department of Otolaryngology of Peking Union Medical Hospital from January to December 2021 were randomly divided into experimental group （n=16）and control group （n=17）when they entered the rotation of head and neck oncological group. The experimental group was taught by MDT combined with CBL. The control group adopted the traditional teaching method. After the teaching, the teaching effect was evaluated by examination and questionnaire survey. The scores of theoretical knowledge test and clinical skill assessment, comprehensive ability and the satisfaction with training of two groups were compared. Results The total assessment score of experimental group was higher than that of control group (190.88±2.87 vs 187.35±4.06, P＜0.01), and their theoretical knowledge and clinical skills assessment scores were higher than those of control group（P＜0.05）. The total score of comprehensive ability in experimental group was higher than that in control group (83.75 ± 3.84 vs 77.94±2.63, P＜0.01), and the scores in learning interest, learning efficiency, clinical thinking, communication skills, and medical record writing were higher than those in control group（P＜0.05）. The questionnaire survey results showed that except for scheduling, the satisfaction of the experimental group's physicians with the training format, content, effectiveness, and practicality was higher than that of control group（P＜0.05）. Conclusion In the clinical teaching of head and neck oncology, compared with the traditional training model, the MDT with CBL teaching model can effectively improve the professional knowledge and clinical skills of resident physicians, with satisfied training effect and strong teaching practicality.