Abstract:ObjectiveTo analyze the relationship between serum neutrophil gelatinase-associated lipocalin（NGAL）and hypertensive patients. Methods The clinical data of 244 hypertensive patients hospitalized in the Department of Cardiology of the South Hospital of Fujian Provincial Hospital from August 2021 to September 2022 were retrospectively included, and they were divided into 122 cases in the low NGAL level group and 122 cases in the high NGAL level group based on the median NGAL level. The serum NGAL level of patients was measured,and relevant clinical indicators such as creatinine,uric acid,and 24-hour ambulatory blood pressure were collected, and the relationship between serum NGAL and various indexes was analyzed. Results The 24-hour mean systolic blood pressure (24 hSBP), daytime mean systolic blood pressure (dSBP), nighttime mean systolic blood pressure (nSBP), white blood cell count, neutrophil count, creatinine level and the prevalence of coronary heart disease in the high NGAL level group were higher than those in the low NGAL level group (P＜0.05).Spearman correlation analysis showed that NGAL was positively correlated with 24hSBP,dSBP,nSBP,white blood cell count, neutrophil count and creatinine, respectively (r=0.465, 0.632, 0.632, 0.834, 0.834, 0.632, P＜0.01）.Univariate linear regression showed that white blood cell count, neutrophil count,creatinine, uric acid, eGFR,24hSBP and nSBP were correlated with NGAL（P＜0.05）. Multivariate linear regression analysis indicated that the increase of neutrophil count was an independent influencing factor for the increase of serum NGAL (P＜0.05). Conclusion There is a correlation between systolic blood pressure level and NGAL in hypertensive patients, and neutrophil count is an influencing factor for the increased NGAL level, suggesting that inflammation may participate in the process of hypertension, and hypertensive patients with high NGAL level are more likely to be complicated with coronary heart disease.