Abstract:ObjectiveTo explore the predictive value of sequential organ failure assessment (SOFA) score combined with procalcitonin (PCT) in the death of sepsis-related acute kidney injury (AKI) elderly patients during hospitalization. Methods A total of 176 patients with sepsis-related AKI hospitalized in the First Affiliated Hospital of Harbin Medical University from January 2018 to December 2022 were retrospectively included. According to the outcome during hospitalization, they were divided into the death group of 62 patients (35.23%) and the survival group of 114 patients (64.77%). The independent risk factors for death during hospitalization and the predicting efficacy of SOFA score and PCT in the death of sepsis-related AKI patients were analyzed. Results Univariate analysis showed that the proportion of age ＞70 years, diabetes, renal replacement therapy, and the levels of prothrombin time, PCT, lactate, APACHE Ⅱ, and SOFA score were all higher in the death group compared to the survival group (P＜0.05). The multivariate logistic regression analysis showed that age＞70 years old (OR=1.241), PCT＞3.40 ng/mL (OR=1.398), APACHE Ⅱ＞25 points (OR=1.706), and SOFA＞8.5 points (OR=1.779) were the independent risk factors for mortality during hospitalization in sepsis-related AKI patients. ROC showed that SOFA score combined with PCT had the highest AUC in predicting the death of sepsis-related AKI patients during hospitalization ［0.855 (95%CI: 0.806-0.904)］. Conclusion SOFA score and PCT are correlated with the prognosis of sepsis-related AKI patients, and their combination can predict the risk of all-cause mortality during hospitalization, thus aiding rapid clinical screening and intervention for high-risk individuals.