Abstract:ObjectiveTo evaluate the operability and safety of mobile CT combined with basic anesthesia in locating pulmonary nodules before uniportal thoracoscopic lung surgery. Methods The clinical data of 72 patients who underwent CT-guided localization before thoracoscopic lung surgery in The Affiliated Brain Hospital of Nanjing Medical University from October 2022 to November 2022 were analyzed. They were divided into group A and group B according to the positioning method. Patients located under local anesthesia were classified as group A （n=36）, patients located under basic anesthesia were classified as group B （n=36）. The clinical data of the two groups were compared. ResultsCompared with group A, in group B, the positioning time was shorter ［（12.75±3.45）min vs（15.00±5.62）min, t=2.047, P=0.045］, the success rate of positioning was higher （100.0%vs83.3%, χ2=4.545, P=0.033）, the number of needle adjustments was less ［0 （0, 0）vs0 （0, 1）］, and the pain score during the positioning process was lower ［1 （0, 2）vs3 （1, 5）］, with statistically significant differences （P＜0.05）. ConclusionCompared with previous local anesthesia, mobile CT combined with basic anesthesia for pulmonary nodules puncture positioning has shorter positioning time, higher success rate and reduced pain sensation of patients, indicating that this method is safe and reliable and worthy of further clinical application.