Abstract:ObjectiveTo investigate the clinical application efficacy of hydroxybutyl chitosan as indocyanine green drug carrier in thoracoscopic pulmonary nodule localization. MethodsThe clinical data of 40 patients received preoperative thoracoscopic pulmonary nodule localization in Taikang Xianlin Drum Tower Hospital from January 2022 to October 2022 was retrospectively analyzed. Among them, 20 cases using hydroxybutyl chitosan drug loaded indocyanine green localization were selected as group A, while 20 cases using indocyanine green localization alone were selected as group B. The localization success rate, localization time, surgical resection time, and the incidence of complications were compared between the two groups. ResultsAll 20 nodules in group A were successfully localized, 2 nodules in group B failed to localize due to pleural contamination, resulting in a longer surgical resection time in group B compared to group A ［（42.30±23.75）min vs（21.25±4.39）min, t=3.898, P＜0.05］. There was no statistically significant difference in localization time, chest pain score, and incidence of complications （pulmonary hemorrhage, pneumothorax） between two groups （P＞0.05）. There was no occurrence of hemothorax or hemoptysis in both groups. ConclusionCompared with indocyanine green alone, hydroxybutyl chitosan drug loaded indocyanine green has a higher success rate and shorter surgical resection time in pulmonary nodule localization prior to video-assisted thoracoscopic surgery, with good safety.