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投稿时间：2023-03-16 网络发布日期：2023-06-20
投稿时间：2023-03-16 网络发布日期：2023-06-20
中文摘要: 目的 探讨益肾固本法针刺是否能改善乳腺癌内分泌治疗患者潮热,并提高生活质量。 方法 连续纳入2019 年 12 月至2020 年 12 月江苏省中医院乳腺外科诊断为激素受体阳性乳腺癌且内分泌治疗后潮热的患者40例,用随机数字表法分为治疗组与对照组各20例。治疗组予益肾固本针刺10周及自我调节,对照组进行自我调节。于治疗前、治疗第 5、10 周进行潮热分数、潮热次数及生存质量评估量表（FACT-B）评估。 结果 治疗组针刺治疗5周、10周时潮热次数与潮热分数较治疗前均显著降低（P＜0.05）;对照组经5周治疗无明显改变（P＞0.05）,10周时显著下降（P＜0.05）;治疗5、10周时治疗组潮热次数、潮热分数均显著低于对照组（P＜0.05）。治疗组针刺10周时 FACT-B量表生理、感情、附加状况，社会家庭与功能状况评分均显著改善（P＜0.05）,对照组治疗后则无明显变化（P＞0.05）,治疗组评分改善均优于对照组（P＜0.05）。 结论 滋肾固本法针刺10周可以显著改善乳腺癌内分泌治疗患者的潮热频率及严重程度,同时可改善患者生存质量。
Abstract:Objective To investigate whether acupuncture with benefiting the kidney and consolidating the essence could improve the hot flash and the quality of life of breast cancer patients with endocrine therapy. Methods From December 2019 to December 2020, 40 patients with hormone receptor positive breast cancer diagnosed in Jiangsu Provincial Hospital of Chinese Medicine were included, and all the patients had hot flashes after endocrine therapy. The patients were divided into treatment group and control group by random number table method (n=20, each) . The treatment group received acupuncture for benefiting the kidney and consolidating the essence for 10 weeks and self-regulation, while the control group received self-regulation only. The scores of hot flashes, frequency of hot flashes, and quality of life assessment scale (FACT-B) were evaluated before and the 5th and 10th weeks of treatment. Results In the treatment group, the number of hot flashes and the hot flashes fraction at 5 and 10 weeks of acupuncture treatment were significantly lower compared with those before treatment (P＜0.05) . In the control group, the treatment did not change significantly by 5 weeks (P＞0.05) and decreased significantly by 10 weeks (P＜0.05) . The number of hot flashes and the hot flush fraction in the treatment group at 5th and 10th week of treatment were significantly lower than those in the control group (P＜0.05) . The physical, emotional, add-on status, social family and functional status scores in FACT-B were significantly improved in the treatment group at 10th week of acupuncture (P＜0.05) , but did not change in the control group after treatment (P＞0.05) , and the scores improved significantly in the treatment group compared with those in the control group (P＜0.05) . Conclusion Acupuncture with benefiting the kidney and consolidating the essence for 10 weeks can significantly improve the frequency and severity of hot flashes in patients undergoing endocrine therapy for breast cancer, as well as improve the quality of patient survival.
keywords: Breast cancer Endocrine therapy Hot flash Acupuncture Benefiting the kidney and consolidating the essence
文章编号： 中图分类号：R246 文献标志码：B
基金项目:中韩国际合作基金 (363); 江苏省自然基金 (BK20221424)
引用文本：
张扬芬,张曦平,汤佳崯,等.益肾固本法针刺改善乳腺癌内分泌治疗后潮热40例临床对照研究[J].中国临床研究,2023,36(6):908-912.
张扬芬,张曦平,汤佳崯,等.益肾固本法针刺改善乳腺癌内分泌治疗后潮热40例临床对照研究[J].中国临床研究,2023,36(6):908-912.