Abstract:Objective To clarify the research history, status, and clinical compatibility law of Dachaihu Decoction by analyzing the relevant literature and medical records. Methods Using the method of literature metrology, the relevant literature of Dachaihu Decoction was searched from 1961 to 2021 in CNKI for statistical analysis of the number of publications, journals, disease type and pharmacological effects. Besides, CiteSpace was used to visually analyze the decoction. Screening the efficacy cases of Dachaihu Decoction in CNKI from 2011 to 2021, a standard prescription database was established, a drug co-occurrence complex network was formed, and conducted cluster analysis. Results A total of 1898 literature was included. From 2011 to 2021, there was an overall upward trend in the number of publications, which were mainly published on the Traditional Chinese Medicine journals. Pharmacological studies mainly focused on its anti-inflammatory, liver protection, cholagogic effect, anti-atherosclerosis and lipid-lowering effects. Meanwhile, Dachaihu Decoction was most frequently used for the treatment of acute pancreatitis, cholecystitis and cholelithiasis. The main research focus was the clinical treatment with Dachaihu Decoction in related diseases. In addition, it showed that Dachaihu Decoction was often used in combination with the herbs such as Jinqiancao, Yujin, Jineijin, etc, while Guizhi Fuling Pill is one of the most commonly used combination prescriptions. Conclusions Dachaihu Decoction is one of the popular clinical and classical prescriptions. However, there still lack of high-level evidence both in clinical research and mechanism detection, which needs further study by subsequent researchers.