Abstract:Objective To observe the level of serum 25-hydroxyvitamin D ［25-（OH）D］level in patients with type 2 diabetes（T2DM） to explore its association with nonalcoholic fatty liver disease（NAFLD） in T2DM patients. Methods A total of 536 patients with T2DM who were admitted to the General Hospital of the Northern Theater from October 2020 to October 2021 were enrolled, including 218 patients without NAFLD(non-NAFLD group) and 318 patients with NAFLD(NAFLD group). The 25-（OH）D levels were compared between two groups. NAFLD fibrosis score（NFS） and fatty liver index（FLI） were used to classify patients with T2DM complicated by NAFLD, and the serum 25-（OH）D levels were compared in the patients with different degrees of liver fibrosis. The multiple logistic regression analysis was performed to analyze the independent influencing factors of liver fibrosis in T2DM patients. Results The levels of parathyroid hormone、waist circumference(WC), TG, AST, ALT, BMI in NAFLD group were significantly higher than those in non-NAFLD group（P<0.05）, and the levels of 25-（OH）D, beta C-terminal telopeptide（β-CTX） and blood phosphorus were significantly lower than those in non-NAFLD group（P<0.05）. The levels of 25-（OH）D in the hepatic fibrosis subgroups were significantly lower than those in the non-hepatic fibrosis subgroups according to NFS and FLI scores (P<0.05). It was suggested that 25-（OH）D and WC were independent influencing factors of liver fibrosis in T2DM patients complicated with NAFLD(P<0.05). ConclusionIn T2DM patients complicated with NAFLD, the serum 25-（OH）D level obviously reduces, which may be indicative of the increased risk of liver fibrosis in the patients.