Abstract:Objective To analyze the effect of laparoscopic side-to-side jejunoileal anastomosis on blood glucose and lipid metabolism in type 2 diabetes mellitus（T2DM） patients. Methods The clinical data of 52 patients with T2DM diagnosed in Jilin Province FAW Hospital from January 2018 to February 2019 who underwent laparoscopic side-to-side jejunoileal anastomosis were retrospectively analyzed. The changes of total cholesterol（TC）, triacylglycerol（TG）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, and glycosylated hemoglobin（HbA1c） before and 3 years after the operation were analyzed. Results Among the 52 patients, 23 had complete remission, 11 had partial remission, 8 had significant improvement, and 10 had no effect at 3 years after surgery. The overall effective rate of blood glucose control was 80.77%. In the control goal of preventing atherosclerosis cardiovascular disease（ASCVD） high-risk groups in T2DM patients, the rate of reaching the target of LDL-C＜2.6mmol/L（74.19% vs 12.90%） and TG＜1.7mmol/L（77.42% vs 48.39%） after surgery were significantly higher than those before surgery（P<0.05）. Among the main targets for extremely high-risk groups, the rate of reaching the standard for LDL-C＜1.8mmol/L after surgery was significantly higher than that before surgery（71.43% vs 7.14%, P<0.01）. After 3 years of follow-up, the levels of TC, TG, LDL-C, and HbA1c were lower than those before surgery（P<0.01）. ConclusionLaparoscopic side-to-side jejunoileal anastomosis can effectively alleviate the abnormal metabolism of blood glucose and lipids in the treatment of T2DM.