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中国临床研究:2023,36(4):633-637
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恶性肿瘤中上皮—间质转化与多种信号通路关系的研究进展
(1. 内蒙古医科大学,内蒙古 呼和浩特 010050;2. 内蒙古医科大学附属医院肝胆胰外科,内蒙古 呼和浩特 010050)
Research progress on the relationship between epithelial-mesenchymal transition and multiple signaling pathways in malignant tumors
摘要
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投稿时间:2022-09-09   网络发布日期:2023-04-20
中文摘要: 近年来,恶性肿瘤的发病率逐年上升,严重危害人类的健康。上皮—间质转化(EMT)在恶性肿瘤侵袭和转移中发挥了关键作用,Wnt、NF-κB、PI3K、TGF等信号通路以及表皮生长因子(EGF)和微小核糖核酸(miRNA)等均参与了EMT的形成过程。本文结合以上信号通路及相关因子对EMT在各系统恶性肿瘤发病和侵袭转移中的作用做简要综述。
Abstract:In recent years, the incidence of malignant tumors is increasing year by year, which seriously endangers human health. Epithelial-mesenchymal transformation(EMT) plays a key role in the invasion and metastasis of malignant tumors. Wnt, NF-κB, PI3K, TGF and other signaling pathways, epidermal growth factor(EGF) and microribonucleic acid(miRNA) are involved in the formation of EMT. This article will briefly review the role of EMT in the pathogenesis, invasion and metastasis of malignant tumors in various systems by combining the above signaling pathways and related factors.
文章编号:     中图分类号:R730    文献标志码:A
基金项目:内蒙古自治区高等学校科学研究项目(NJZZ22651);内蒙古医疗卫生科技计划项目(20201331)
引用文本:
解文浩,王飞,赵海平,等.恶性肿瘤中上皮—间质转化与多种信号通路关系的研究进展[J].中国临床研究,2023,36(4):633-637.

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