Abstract:Objective To explore the impacts of electronic bronchoscope alveolar lavage（BAL） combined with ambroxol bydrochloride on clinical efficacy, inflammatory factors and arterial blood gas indexes in the patients with severe pneumonia after stroke. Methods Eighty-six patients with severe post-stroke pneumonia admitted to Nanchong Central Hospital from January 2020 to August 2021 were selected and randomly divided into observation group and control group（n=43,each）. The electronic BAL through the three-way inferface combined with ambroxol hydrochloride was conducted in control group, while the sputum suction and lavage combined with ambro×01 hydrochloride were performed quickly under oxygen inhalation with intermittent mechanical ventilation in observation group. The clinical efficacy 1 week after treatment, the serum inflammatory factors and arterial blood gas indexes were compared before and after treatment. Results The total effective rate in observation group was similar to that in control group（76.74% vs 81.40%, P＞0.05）. After treatment for 1 week, the level of procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6(IL-6) were statistically lower than those before treatment in two groups（P＜0.01）, but there were no significant differences between two groups（P＞0.05）. The oxygen partial pressure increased significantly, the carbon dioxide partial pressure decreased significantly(P＜0.05), and pH value exhibited no significant change compared with those before treatment in two groups（P＞0.05）.There were no significant differences in the three indicators between two groups（P＞0.05）. Conclusion Under oxygen inhalation with intermittent disconnection of mechanical ventilation, rapid sputum suction and lavage using electronic bronchoscope combined with ambroxol hydrochloride, and electronic bronchoscope BAL through the three-way interface combined ambro×01 hydrochloride have the same curative effect. It can also alleviate inflammatory reaction and improve arterial blood gas indicators.