Abstract:Severe asthma accounts for only a small proportion of all asthmatic patients, but its the main cause of disability and death of them, and brings heavy social and economic burden to the society. Severe asthma usually requires high-dose inhaled corticosteroid（ICS) and oral corticosteroids, which can cause a series of side effects. In recent years, new therapies such as biotargeted therapy and bronchial thermoplasty have continued to develop. This review summarizes status and prospects in treatment of severe asthma, aiming to provide a reference for personalized treatment and improvement of quality of life in severe asthma patients.