本文已被：浏览 466次 下载 427次
投稿时间：2022-12-27 网络发布日期：2023-02-20
投稿时间：2022-12-27 网络发布日期：2023-02-20
中文摘要: 目的 探讨肺炎支原体IgM抗体（MP-IgM）、降钙素原（PCT）、超敏C反应蛋白（hs-CRP）联合检测在儿童肺炎支原体感染中的应用及其诊断价值。方法 选取2022年8月至12月南京江北医院儿科就诊的肺炎支原体感染患儿58例为感染组，另选取同期体检健康儿童59例为对照组。分析hs-CRP、PCT及MP-IgM联合检测在儿童肺炎支原体感染中的诊断价值。结果 与对照组相比，感染组PCT和hs-CRP水平均高于对照组（P＜0.05）。感染组MP-IgM阳性率高于对照组（75.9% vs10.2%, P＜0.05）。MP-IgM诊断MP感染的灵敏度为75.9%，特异性为89.8%，阳性预测值为88.0%，阴性预测值为79.1%，准确度为82.9%。采用ROC曲线分析PCT和hs-CRP在肺炎支原体感染时，PCT和hs-CRP的曲线下面积（AUC）分别为0.672、0.640，与MP-IgM联合检测诊断小儿肺炎支原体感染灵敏度为91.3%，特异性为88.1%，阳性预测值为88.3%，阴性预测值为91.1%，准确度为89.7%。结论 PCT、hs-CRP对儿童肺炎支原体感染的诊断有一定的应用价值，与传统的MP-IgM检测联合应用可有效提高检测阳性率，联合检测的灵敏度、阴性预测值、准确度均高于单独MP-IgM检测，可弥补单纯MP-IgM检测的不足。
Abstract:ObjectiveTo investigate the diagnostic value of Mycoplasma pneumoniae IgM antibody(MP-IgM), procalcitonin(PCT) and hypersensitive C-reactive protein(hs-CRP) combined detection in children with Mycoplasma pneumoniae infection. MethodsFifty-eight children with Mycoplasma pneumoniae infection in Nanjing Jiangbei Hospital from August 2022 to December 2022 were selected as the infection group, and 59 healthy children in the same period were selected as the control group. The diagnostic value of combined detection of hs-CRP, PCT and MP-IgM in children with Mycoplasma pneumoniae infection was compared and analyzed. ResultsCompared with the control group, the levels of PCT and hs-CRP in the infection group were higher than those in the control group(P＜0.05). The positive rate of MP-IgM in the infection group was higher than that in the control group (75.9% vs10.2%, P＜0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MP-IgM in the diagnosis of MP infection were 75.9%, 89.8%, 88.0%, 79.1% and 82.9%, respectively. The area under the curve(AUC) of PCT and hs-CRP were 0.672 and 0.640 respectively when analyzed by ROC curve. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of combined detection of PCT and hs-CRP with MP-IgM were 91.3%, 88.1%, 88.3%, 91.1% and 89.7% respectively. ConclusionsPCT and hs-CRP have certain application value in the diagnosis of Mycoplasma pneumoniae infection in children. The combination of PCT and hs-CRP with traditional MP-IgM detection can effectively improve the positive rate of detection. The sensitivity, negative predictive value and accuracy of the combined detection are higher than that of single MP-IgM detection, which can make up for the deficiency of the positive rate of pure MP-IgM detection.
keywords: Mycoplasma pneumoniae Mycoplasma pneumoniae IgM antibody Procalcitonin Hypersensitive C-reactive protein Pneumonia Children
文章编号： 中图分类号： 文献标志码：B
基金项目:
| 作者 | 单位 |
| 杨帆1 | 1. 南京市江北新区公共卫生服务中心妇幼保健所检验科，江苏 南京 210048； |
| 张仁和2 | 2. 南通大学附属南京江北医院检验科，江苏 南京 210048； |
| 徐新润2 | 2. 南通大学附属南京江北医院检验科，江苏 南京 210048； |
| 陈久应2 | 2. 南通大学附属南京江北医院检验科，江苏 南京 210048 |
引用文本：
杨帆,张仁和,徐新润,等.肺炎支原体IgM抗体、PCT、超敏C反应蛋白联合检测对儿童肺炎支原体感染的诊断价值[J].中国临床研究,2023,36(2):295-298.
杨帆,张仁和,徐新润,等.肺炎支原体IgM抗体、PCT、超敏C反应蛋白联合检测对儿童肺炎支原体感染的诊断价值[J].中国临床研究,2023,36(2):295-298.