Abstract:Objective To investigate clinical effect of Bushen Wenjing Decoction in the treatment of male infertility with abnormal sperm acrosin(oligozoospermia and asthenospermia). Methods A total of 64 male oligozoospermia and asthenospermia patients with abnormal sperm acrosin from June 2017 to May 2020 in Nanjing Jiangbei Hospital were selected and divided into observation group and control group randomly(n=32, each). The control group was treated with anti-oxidation+regulation of sperm energy metabolism, taking vitamin C+vitamin E and coenzyme A intramuscular injection. The observation group was treated with the self-made Chinese medicine Bushen Wenjing Decoction. Three months was a course of treatment. The total effective rate, semen parameters and acrosin activity of the two groups were observed. Results After treatment, the sperm normal morphology rate, sperm viability rate, sperm rate of grade a+b and sperm acrosin activity of the two groups were higher than those before treatment, and the observation group was significantly higher than the control group(P＜0.05). The total effective rate of the observation group was significantly higher than that of the control group(90.63% vs 56.25%, χ²=9.692, P=0.002). Conclusion Bushen Wenjing Decoction can significantly improve the sperm acrosin activity, sperm quality and fertility of oligoasthenospermia patients.