Abstract:Objective To observe the effect of patting along meridians combined with Geqi formula on the quality of life of patients with perimenopausal syndrome. Methods Ninety women with perimenopausal syndrome treated in Dongzhimen Hospital of Beijing University of Chinese Medicine from December 2021 to January 2022 were selected and randomly divided into patting along the meridian group, Geqi formula group and combination group(n=30, each). The meridian beating exercise was performed five times a week for half an hour each time in patting along the meridian group, Geqi formula granules were given a one dose per day in Geqi formula group, and the above two treatment regimens were conducted in combination group. The course of treatment was 12 weeks in three groups. The modified Kupperman score, the short form-36 quality of life scale(SF-36), traditional Chinese medicine (TCM) syndrome score for perimenopausal syndrome, the levels of estrogen (E₂), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and bone mineral density (BMD) were observed before and after treatment to evaluate and compare the efficacy among three groups. Results After intervention, the modified Kupperman score, SF-36 score, TCM syndrome score and the levels of E₂, FSH and LH were significantly improved in three groups (P＜0.01), and they were better in combination group than those in other two groups(P＜0.01). There was no statistically significallt difference in BMD between three groups(P＜0.05). Conclusion Meridian beating method combined with Geqi formula can effectively improve the uncomfortable symptoms of women with perimenopausal syndrome and their quality of life with safety.