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投稿时间：2022-11-26 网络发布日期：2022-12-20
投稿时间：2022-11-26 网络发布日期：2022-12-20
中文摘要: 目的 探讨冠心病慢性心力衰竭患者尿中中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平变化及临床意义。方法 选择南京江北医院于2017年至2018年收治的冠心病慢性心力衰竭患者163例作为观察对象；另选择2017至2018年期间健康体检者50例作为对照组。所有研究对象均采集晨起中段尿，采用胶体金方法测定NGAL含量。比较两组尿NGAL含量和心功能指标变化及不同心功能分级尿NGAL含量和心功能指标变化，分析尿NGAL与心功能指标相关性。结果 研究组尿NGAL水平和LVEDD高于对照组，LVEF低于对照组，差异有统计学意义（P＜0.05）。Ⅳ级组尿NGAL水平和LVEDD高于Ⅲ级组和Ⅱ级组，LVEF低于Ⅲ级组和Ⅱ级组，差异有统计学意义（P＜0.05）；Ⅲ级组尿NGAL水平和LVEDD高于Ⅱ级组，LVEF低于Ⅱ级组，差异有统计学意义（P＜0.05）。NGAL与LVEF呈线性负相关，而与LVEDD呈线性正相关（P＜0.05）。结论 冠心病慢性心力衰竭患者尿中NGAL水平明显升高，且随着病情加重升高越明显，可作为判断其病情一项辅助性指标。
中文关键词: 冠心病慢性心力衰竭 中性粒细胞明胶酶相关脂质运载蛋白 心功能 肾损害
Abstract:Objective To investigate the changes and clinical significance of urinary neutrophil gelatinase associated lipid transporter (NGAL) in patients with coronary heart disease and chronic heart failure. Methods One hundred and sixty-three patients with coronary heart disease and chronic heart failure admitted from Nanjing Jiangbei Hospital from 2017 to 2018 were selected as observation objects. In addition, 50 healthy people from 2017 to 2018 were selected as the control group. All subjects collected morning urine and determined NGAL content by colloidal gold method. The changes of urinary NGAL content and cardiac function indexes were compared between the two groups, and the changes of urinary NGAL content and cardiac function indexes were compared between different concentric function grades. The correlation between urinary NGAL and cardiac function indexes were analyzed. Results Urine NGAL and LVEDD in the study group were higher than those in the control group, while LVEF was lower than those in the control group, with significant difference(P＜0.05). The urine NGAL content and LVEDD in grade Ⅳ group were higher than those in grade Ⅲ and grade Ⅱ groups, and LVEF was lower than those in grade Ⅲ and grade Ⅱ groups(P＜0.05). The urine NGAL content and LVEDD in grade Ⅲ group were higher than those in grade Ⅱ group, and LVEF was lower than those in Grade Ⅱ group, with significant difference(P＜0.05). NGAL was negatively correlated with LVEF and positively correlated with LVEDD(P＜0.05). Conclusion The level of NGAL in urine of patients with chronic heart failure caused by coronary heart disease is significantly increased, and the increase is more obvious with the aggravation of the disease. It can be used as an auxiliary indicator to judge the condition of patients with chronic heart failure.
keywords: Chronic heart failure in coronary heart disease Neutrophil gelatinase-related lipoprotein Cardiac function Renal damage
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附件
| 作者 | 单位 |
| 杨帆1 | 1. 南京市江北新区公共卫生服务中心妇幼保健所检验科，江苏 南京 210048 |
| 王玉蓉2 | 2. 南通大学附属南京江北医院检验科，江苏 南京 210048 |
| 许培培3 | 3. 南京市六合区疾病预防控制中心，江苏 南京 211500 |
引用文本：
杨帆,王玉蓉,许培培.冠心病慢性心力衰竭患者尿中性粒细胞明胶酶相关脂质运载蛋白水平变化[J].中国临床研究,2022,35(12):1709-1712.
杨帆,王玉蓉,许培培.冠心病慢性心力衰竭患者尿中性粒细胞明胶酶相关脂质运载蛋白水平变化[J].中国临床研究,2022,35(12):1709-1712.