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投稿时间：2022-02-09 网络发布日期：2022-12-20
投稿时间：2022-02-09 网络发布日期：2022-12-20
中文摘要: 目的 探讨多囊卵巢综合征（PCOS）患者血清抗苗勒管激素(AMH)、胰岛素样生长因子-1（IGF-1）与PCOS的相关性。方法 选择2017年1月至2018年1月在三峡大学附属仁和医院就诊的年龄20~32岁的PCOS患者58例作为PCOS组，并选择年龄匹配的60例健康者作为对照组，将PCOS组分为非肥胖PCOS组33例，肥胖PCOS组25例；将健康对照组分为非肥胖对照组32例和肥胖对照组28例。测定PCOS组血清AMH、IGF-1、总睾酮(T)、促黄体生成素(LH)、雌二醇(E2)、促卵泡生成素(FSH)及空腹胰岛素(FINS)、空腹血糖(FBG)等指标，并与对照组进行比较。结果 肥胖PCOS组及〖JP+1〗肥胖对照组BMI、HOMA-IR、FINS显著高于对应的非肥胖组（P＜0.05）；肥胖PCOS组及非肥胖PCOS组HOMA-IR、FINS以及T、LH、LH/FSH、AMH、IGF-1显著高于对应的对照组（P＜0.05）。AMH与E2、T、LH、LH/FSH、HOMA-IR呈正相关（P<0.05）；IGF-1与FINS、HOMA-IR呈正相关（P<0.05）。结论 PCOS中血清AMH、IGF-1水平升高，AMH与E2、T、LH、LH/FSH、HOMA-IR呈正相关；IGF-1与FINS、HOMA-IR呈正相关;提示AMH和IGF-1在PCOS发病机制中的作用。
中文关键词: 多囊卵巢综合征 抗苗勒管激素 胰岛素样生长因子-1 胰岛素抵抗
Abstract:Objective To investigate the correlation between serum anti-Müllerian hormone(AMH) and insulin-like growth factor-1(IGF-1) and polycystic ovary syndrome(PCOS). Methods A total of 58 PCOS patients aged 20-32 years who visited Affiliated Renhe Hospital of Three Gorges University from January 2017 to January 2018 were selected as the PCOS group, and 60 age-matched healthy people were selected as the control group. The PCOS group was divided into non-obese PCOS group （n=33） and obese PCOS group （n=25） ; The healthy control group was divided into non-obese control group (n=32) and obese control group (n=28). Serum AMH, IGF-1, total testosterone (T), luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), fasting insulin (FINS), fasting blood glucose (FBG) and other related indicators were measured in PCOS group and compared with the control group. Results BMI, homeostasis model assessment of insulin resistance(HOMA-IR) and FINS in obese PCOS group and obese control group were significantly higher than those in corresponding non-obese groups(P＜0.05). HOMA-IR, FINS, T, LH, LH/FSH, AMH and IGF-1 in obese PCOS group and no-obese PCOS group were significantly higher than those in corresponding control group(P＜0.05). AMH was positively correlated with E2, T, LH, LH/FSH and HOMA-IR（P<0.05）, and IGF-1 was positively correlated with FINS and HOMA-IR（P<0.05）, respectively. Conclusion Serum AMH and IGF-1 levels increase in PCOS patients， and AMH is positively correlated with E2, T, LH, LH/FSH and HOMA-IR, IGF-1 is positively correlated with FINS and HOMA-IR, suggesting their roles in the pathogenesis of PCOS.
keywords: Polycystic ovary syndrome Anti-Müllerian hormone Insulin-like growth factor-1 Insulin resistance
文章编号： 中图分类号： 文献标志码：A
基金项目:湖北省教育厅科学研究计划指导性项目（B2017019）
| Author Name | Affiliation |
| DING Fang, YI Xiao-fang | Department of Gynecology and Obstetrics,Affiliated Renhe Hospital of Three Gorges University,Yichang, Hubei 443001, China |
引用文本：
丁芳,易晓芳.血清抗苗勒管激素和胰岛素样生长因子-1与多囊卵巢综合征的相关研究[J].中国临床研究,2022,35(12):1658-1661.
丁芳,易晓芳.血清抗苗勒管激素和胰岛素样生长因子-1与多囊卵巢综合征的相关研究[J].中国临床研究,2022,35(12):1658-1661.