Abstract:Objective To explore the risk factors of postoperative peripherally inserted central catheter(PICC)-related infection in patients with colorectal cancer (CRC).Methods A total of 98 patients with CRC received central venous catheter puncture in the First Affiliated Hospital of Hainan Medical University from January 2019 and March 2022 were selected. According to presence or absence of PICC-related infection, they were divided into infection group (35 cases) and non-infection group (63 cases). The clinical data (gender, age, education level, comorbidities, chemotherapy, and central venous indwelling) and laboratory examination indexes (immune-related indexes, routine blood test, inflammatory factors) in both groups were statistically analyzed. The risk factors of PICC-related infection were analyzed by multivariate logistic regression analysis. Results The percent of patients with diabetes history, white blood cell count<4×109/L，puncture times≥2, catheterization time≥3 months and chemotherapy times≥4 times in infection group were higher than that in non-infection group (P<0.01). The results of multivariate logistic regression analysis showed that diabetes history, white blood cell count<4×109/L，puncture times≥2, catheterization time≥3 months and chemotherapy times≥4 times were independent risk factors of postoperative PICC-related infection in CRC patients (P<0.05).Conclusions There are complex and diverse factors related to postoperative PICC-related infection in CRC patients. In clinical nursing, catheter management should be strengthened, and targeted intervention should be carried out.