Abstract:Objective To investigate the effects of sevoflurane and propofol combined with remifentanil anesthesia on respiratory and circulatory system and postoperative sleep quality in patients received radical resection of esophageal cancer.Methods A total of 100 esophageal cancer patients with radical resection in Shanghai Ninth Peoples Hospital from March 2019 to August 2021 were selected and randomly divided into observation group and control group ( n=50, each). After anesthesia induction, the continuous target-controlled infusion of propofol combined with remifentanil was given in control group, and sevoflurane inhalation with target-controlled infusion of remifentanil was performed in observation group. The heart rate(HR), mean arterial pressure (MAP), respiratory rate (RR), end-expiratory carbon dioxide partial pressure (PETCO2), airway pressure (PAW) were observed and recorded before anesthesia (T1), at the time of skin-cutting(T2),at the end of operation (T3) and at extubation (T4). Pittsburgh Sleep Quality Index (PSQI) and Assen Insomnia Scale (AIS) were used to evaluate the sleep quality before operation and at 1-, 3-, 7-and 30-day after operation. The adverse reactions were recorded after operation. Results MAP and HR at T2and T3 were significantly lower than those at T1 in both groups (P<0.05). The levels of PAW and PETCO2 at T2and T3 were significantly higher than those at T1 in control group and those in observation group at the same time points (P<0.05). Compared with those in control group, PSQI score and AIS score significantly decreased at 1-, 3-and 7-day after surgery, and urinary melatonin level significantly increased at 3 and 7 days after surgery in observation group (P<0.05). The levels of PSQI, AIS and melatonin in the two groups at 30 days after operation were similar to those before operation (P>0.05). Compared with those in control group, VAS score significantly decreased, and the time of awakening and extubation were significantly shorter in observation group (P<0.01). There was no significant difference in the incidence of adverse reactions between control group and observation group (16.00% vs 10.00%, P>0.05). Conclusions Sevoflurane combined with remifentanil general anesthesia can stabilize the vital signs and the function of respiratory and circulatory system, with little impact on postoperative sleep quality in the patients undergoing radical resection of esophageal cancer.