Abstract:Objective To explore the diagnostic value of combined detection of peripheral blood neutrophil/lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and squamous cell carcinoma-related antigen (SCC-Ag) in cervical cancer. Methods A total of 80 patients with confirmed cervical cancer (cervical cancer group), 80 patients with cervical precancerous lesions (precancerous lesions group) and 80 women with normal physical examination (control group) were selected between June 2013 to December 2021 in Affiliated Hospital of Yangzhou University. WBC, PLT, neutrophil count, lymphocyte count and SCC-Ag were detected in three groups, and NLR and PLR were calculated. ROC curve was used to analyze the diagnostic values of NLR, PLR and SCC-Ag in cervical cancer. The logistic regression model of combination of NLR, PLR and SCC-Ag was established to analyze the diagnostic value for cervical cancer. Results NLR, PLR and SCC-Ag in cervical cancer group were significantly higher than those in precancerous lesions group and control group (P<0.05).ROC curve analysis showed that NLR, PLR and SCC-Ag had certain clinical significance for the diagnosis of cervical cancer. The AUCs of NLR, PLR and SCC-Ag in single diagnosis and combined diagnosis of cervical cancer were 0.791, 0.787, 0.825 and 0.904, respectively. The efficacy of combined diagnosis was significantly higher than that of single diagnosis (P<0.01). Conclusion The combined detection of NLR, PLR and SCC-Ag can improve the diagnostic efficiency for cervical cancer.