Abstract:ObjectiveTo explore the value of soluble growth stimulation expressed gene 2 protein(sST2) and asymmetric dimethylarginine(ADMA) in predicting the acute attack of patients with asthma. Methods A prospective study was conducted on the patients with asthma in Peking University Shenzhen Hospital from January 2018 to October 2020. Telephone follow-up for the patients was performed to record the occurrence of acute attacks within 3 months. According to the outcome, the patients were divided into stable group and risk group. The baseline data balance was compared between two groups. The parameters that possibly affected the prognosis of asthma were included in the univariate analysis，in which the meaningful indicators were included in a multivariate Cox regression model to obtain the indexes with predictive value for the acute attack of asthma. The ROC curve was used to analyze the predictive value of individual or combined detection of each index for acute asthma attack. Results Of 194 patients with asthma enrolled, there were 21 patients with acute attacks,173 patients did not have acute attacks within 3 months. Multivariate Cox regression showed that high sST2 level(HR=1.107, 95%CI:1.057-1.160，P＜0.01) and high ADMA level(HR=1.076, 95%CI：1.020-1.135，P＜0.01) were the independent predictors of acute asthma attack. ROC curve analysis showed that the combined AUC value of sST2 (cut-off value 18.0 ng/ml) and ADMA (cut-off value 0.54 μmol/L) in predicting acute attack of asthma patients was higher than that of sST2 (0.766) and ADMA (0.742) alone prediction (P<0.05). Conclusion In the patients with asthma, sST2 and ADMA are the predictors of acute attack risk, and the combined detection of them has a stronger predictive value.