Abstract:Objective To investigate the effect of Shenqi Huoxue Decoction in the treatment of type 2 diabetes mellitus（T2DM） patients with lower extremity vascular disease and the effect on serum visceral adipose-specific serine protease inhibitor（Vaspin） and angiopoietin like protein 4（ANGPTL4）levels. Methods A total of 120 patients with diabetic lower extremity vascular diseases admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2019 to May 2021 were selected and randomly divided into observation group（n=60） and control group（n=60）. The conventional Western medicine and buflomedil hydrochloride were used in control group, and Shenqi Huoxue decoction was used in observation group on the basis of the control group. After 3 months of treatment, TCM syndrome score, hemodynamics, levels of Vaspin, ANGPTL4 and inflammatory factors and incidence of adverse reactions were compared between two groups. Results At 1- and 3-month after treatment, TCM syndrome scores were gradually decreased in two groups（P＜0.01） and were statistically lower in observation group than those in control group（P＜0.05）. Compared with control group, the levels of peak arterial flow velocity（PFV）, pulsatility index（PI）, and serum levels of Vaspin and ANGPTL4 significantly increased（P＜0.01，P＜0.05）, and the levels of TNF-α and IL-6 deceased in observation group（P＜0.05）. There was no statistical difference in the incidence of adverse drug reactions between two groups（P＞0.05）. Conclusion Buflomedil hydrochloride combined with Shenqi Huoxue Decoction in the treatment of diabetic lower extremity vascular lesions with TASC grade B and below may increase the serum Vaspin and ANGPTL4 levels, inhibit the bodys inflammatory response, and promote lower extremity blood circulation, thereby effectively improving the clinical symptoms of patients.