Abstract:Objective To explore the relationship between health information literacy (HIL)and medication adherence in patients with chronic kidney disease(CKD). Methods The convenience sampling method was used to select 289 CKD patients hospitalized in the department of Nephrology of a level-A tertiary hospital in Chengdu from December 2020 to March 2021. The general data questionnaire, the HIL questionnaire and the Morisky Medication Adherence Scale were used for questionnaire survey. Pearson correlation analysis and multiple linear regression were performed to explore the correlation between HIL levels and medication adherence. Results There were 281 CKD patients who completed the survey, and the total score of medication adherence was 5.63±1.92, with low, medium and high levels accounting for 51.60%, 33.45% and 14.95%, respectively. The total score of HIL was 95.00±14.74. Correlation analysis results showed that there was a positive correlation between HIL score and medication adherence (P＜0.05). Multiple regression analysis showed that complications, dialysis modalities, acquisition ability in HIL and CKD health knowledge reserve were the influencing factors for medication adherence(P＜0.05). Conclusion The level of HIL affects the medication adherence of CKD patients, and increasing the level of HIL is helpful to improve the medication adherence.