Abstract:Objective To investigate the clinical effect of ultrasound-guided acupotomy combined with drug injection on knee osteoarthritis (KOA). Methods Eighty KOA patients treated in Linyi People’s Hospital from June 2020 to July 2021 were randomly divided into control group(n=40，2 patients lost to follow-up) and observation group(n=40). The ultrasound-guided knee injection (sodium hyaluronate with betamethasone) was conducted in control group, and the ultrasound-guided acupotomy therapy was performed based on drug injection in observation group. Western Ontario and McMaster University Osteoarthritis Index (WOMAC), visual analogue scale of pain (VAS) and effusion depth of the suprapatellar bursa were observed and compared before and after treatment and 2 months’ follow-up between two groups. Results After treatment and 2 months follow-up, WOMAC score, VAS score and effusion depth of the suprapatellar bursa were significantly superior to those before treatment in both groups （P＜0.01），but there was no statistical difference in them between two groups（P＞0.05）. At the end of 2 months’ follow-up, the above indicators in observation group were significantly better than those in control group (P<0.01). Conclusion Ultrasound-guided acupotomy combined with drug injection has a positive effect on knee osteoarthritis, and the long-term effect is better than that of drug injection on knee joint alone.