Abstract:Objective To investigate the relationship between serum cholyglycine level and pregnancy outcome in intrahepatic cholestasis of pregnancy (ICP). Methods A retrospective analysis was performed on 73 patients with ICP admitted to Wuxi Maternal and Child Health Hospital from January to December 2020 (ICP group), and 73 normal pregnant women at the same period were served as control group. Cholyglycine level was detected by electrochemiluminescence (ECL), and the relationship between serum cholyglycine level and pregnancy outcome was analyzed. Results The serum cholyglycine level in ICP group was significantly higher than that in control group ［(15.50±9.01) μg/ml vs (1.15±0.64) μg/ml, P＜0.05］. The incidences of postpartum hemorrhage (10.96% vs 1.37%), fetal distress (16.44% vs 4.11%), neonatal asphyxia (10.96% vs 1.37%), preterm delivery (26.03% vs 6.85%) and amniotic fluid contamination (24.66% vs 5.48%) in ICP group were significantly higher than those in control group （P<0.05， P<0.01）. The Apgar score of newborns in ICP group was significantly lower than that in control group (7.95±1.52 vs 9.02±1.45, P<0.01). In ICP group, the pregnant women were divided into low (≤10 μg/ml), middle （>10-15 μg/ml）and high （≥15 μg/ml）cholyglycine level groups, and the incidence of fetal distress increased with the increase of serum cholyglycine level (P<0.05), while the neonatal Apgar score decreased with the increase of serum cholyglycine level (P<0.01). Conclusion ICP has a significant impact on pregnancy outcome. The increased serum cholyglycine level has a certain value in predicting pregnancy outcome. Monitoring serum glycocholic acid is conducive to the early clinical treatment and the decreased incidence of adverse outcomes.