Abstract:The incidence of diabetic cardiomyopathy increases with the increasing rate of diabetes mellitus. Diabetic cardiomyopathy is initially characterized by myocardial fibrosis, dysfunctional remodeling and associated diastolic dysfunction, followed by systolic dysfunction, finally leading to clinical heart failure. Exosomes are a subgrouPof extracellular vesicles, which are enriched in a variety of bioactive lipids, receptors, transcription factors, surface proteins, DNA and non-coding RNA. They regulate the physiological process of recipient cells by carrying bioactive molecules from host cells and play an important role in mediating intercellular signals. Studies have shown that the cellular proteins and non-coding RNA carried by exosomes from various types of cardiomyocytes play a key role in cardiac remodeling of the patients with ventricular hypertrophy and other diseases. This review summarizes the research progress of exosomes in the pathogenesis of diabetic cardiomyopathy.