Abstract:ObjectiveTo explore the feasibility of perihilar surgical techniques in the treatment of complicated intrahepatic cholangiolithiasis. Methods The clinical data of 6 patients with complicated intrahepatic cholangiolithiasis were retrospectively analyzed, who admitted to the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University from June to November 2021.Three patients underwent left lateral hepatic lobectomy combined with biliary-intestinal drainage in local hospital due to intrahepatic cholangiolithiasis. There were six patients admitted to hospital with intrahepatic cholangiolithiasis and hilar bile duct stenosis or postoperative anastomotic stenosis and four patients with intermittent jaundice before operation. Results The procedures were completed by perihilar surgical techniques in all 6 patients, including 1 case operated combined with right-posterior lobe hepatectomy, 1 case treated combined with left hemi hepatectomy, 3 cases operated combined with resection of residual left hepatic lobe and bilio-enteric anastomosis for biliary reconstruction and 1 case operated combined with lithotomy via median hepatic fissure. The operation time was 110-215 min, with an average of 150 min. The average volume of intraoperative blood loss was 220 ml (130-470 ml). The patients were given enhanced recovery after surgery in the perioperative period of surgery. No postoperative complications occurred, such as biliary leakage, bleeding, liver insufficiency and ascites. Postoperative hospital stay ranged from 10 to 15 days, with an average of 12 days. Conclusion Perihilar surgical techniques can be used in the treatment of complicated intrahepatic cholangiolithiasis and is worth to popularize.