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投稿时间：2022-04-07 网络发布日期：2022-05-20
投稿时间：2022-04-07 网络发布日期：2022-05-20
中文摘要: 目的 探讨血脂水平与IBD疾病活动度的相关性及载脂蛋白（APO）B/A-1比值对活动性IBD的预测价值。方法 纳入2019年1月至2020年12月在南京鼓楼医院住院的271例IBD患者和271例健康对照者，分析两组APOA-1、APOB、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平差异。同时评价IBD患者临床和内镜活动指数，以及C反应蛋白（CRP）、粪钙卫蛋白（FC）水平，探讨血脂与IBD疾病活动度的关系，比较APOB/A-1比值在缓解期和活动期IBD之间的差异。结果 271例IBD患者中克罗恩病（CD）患者224例，溃疡性结肠炎（UC）患者47例。与对照组相比，克罗恩病（CD）组及溃疡性结肠炎（UC）组的APOA-1、APOB、TC、HDL-C、LDL-C水平均降低（P<0.05）。与缓解期CD相比，活动期的APOB/A-1比值升高，且在重度活动性CD中最高（P<0.05）。随着APOB/A-1>0.68时，重度活动性CD的风险增加（P<0.05）。结论 IBD患者与健康人群血脂水平不同，且APOB/A-1对重度活动性CD具有预测价值。
Abstract:ObjectiveTo explore the correlation between blood lipid levels and IBD disease activity and the predictive significance of apolipoprotein (APO) B/A-1 ratio in active IBD. Methods A total of 271 IBD patients and 271 healthy controls who were hospitalized in Nanjing Drum Tower Hospital from January 2019 to December 2020 were seleeted. The differences in APOA-1, APOB, TG, TC, HDL-C, and LDL-C levels between the two groups were analyzed. The clinical and endoscopic activity indices, as well as C-reactive protein (CRP) and fecal calprotectin (FC) levels were also evaluated in patients with IBD, and the APOB/A-1 ratio was compared between remission and active IBD. Results A total of 271 IBD patients were included, including 224 patients with Crohn's disease (CD) and 47 patients with ulcerative colitis (UC). Compared with the control group, the levels of APOA-1, APOB, TC, HDL-C and LDL-C in the CD grouPand UC grouPwere decreased (P<0.05). Compared with CD in remission, the APOB/A-1 ratio in active phase was higher, and it was the highest in severe active CD (P<0.05). With APOB/A-1>0.68, the risk of severe active CD increased (P<0.05). Conclusion IBD patients and healthy people have different blood lipid levels, and APOB/A-1 has predictive value for severe active CD.
keywords: Apolipoprotein Inflammatory bowel disease Crohn's disease Ulcerative colitis Disease activity
文章编号： 中图分类号： 文献标志码：A
基金项目:国家自然科学基金面上项目（82170548）
引用文本：
施丹丹1,彭春艳2,窦晓坛2,等.血脂异常及载脂蛋白B/A-1比值对炎症性肠病活动度的预测价值[J].中国临床研究,2022,35(5):613-616,621.
施丹丹1,彭春艳2,窦晓坛2,等.血脂异常及载脂蛋白B/A-1比值对炎症性肠病活动度的预测价值[J].中国临床研究,2022,35(5):613-616,621.