Abstract:Objective To explore the effects of pressing needle therapy on the degree of fatigue, quality of life and motor function in patients with post-stroke fatigue on the basis of routine intervention. Methods Sixty patients with post-stroke fatigue treated in Jiangsu Province Hospital of Chinese Medicine from May 2020 to August 2021 were selected and randomly divided into control group （n=28,finally included） and intervention group （n=29, finally included）. The conventional treatment was given in control group, and pressing needle therapy was conducted in intervention group on the basis of conventional treatment. The clinical therapeutic effects were compared between two groups. Results Before intervention, there were no significant differences in general information and the scores on degree of fatigue, quality of life and motor function between two groups （P＞0.05）. After 2 weeks of intervention, fatigue severity scale （FSS） significantly decreased compared with that before intervention in two groups and was significantly lower in intervention group than that in control group; the stroke specific quality of life scale （SS-QOL） total score and enery component (SS-QOL-E) score significantly increased in both groups and were higher in intervention group than those in control group （P ＜0.05, P＜0.01）. After 2 weeks of intervention, except for the hamstring muscle strength of control group, the FMA scores of the upper and lower limbs and the target muscle strength grades of the two groups were significantly improved compared with those before intervention (P<0.05)，while the FMA scores of upper and lower limbs and the muscle strength grades of shoulder adductor, biceps brachii, triceps brachii in intervention group were statistically higher than those in control group (P<0.05, P<0.01). Conclusion Pressing needle therapy can effectively alleviate the symptoms of post-stroke fatigue, and improve the quality of life and motor function in the patients with post-stroke fatigue.