Abstract:Objective To explore the clinical efficacy of ultrasound-guided compound betamethasone combined with needle knife therapy in the treatment of stenotic tenosynovitis of thumb flexor tendon. Methods A total of 62 patients with stenotic tenosynovitis of thumb flexor tendon in Linyi People's Hospital from July 2020 to April 2021 were randomly divided into observation group and control group, with 31 cases in each group. The control group was treated with drug injection under the guidance of ultrasound, and the observation group was treated with needle knife therapy on the basis of the control group. VAS score, Quinnell grade and clinical efficacy of the two groups were evaluated, and the changes of tendon were observed. Results Finally, there were 29 cases in the observation group and 29 cases in the control group. Compared with 1 week after treatment, the VAS score of the observation group decreased significantly ［（1.97±1.24） points vs （2.83±0.93） points, P＜0.05］, and that of the control group decreased significantly ［（3.07±1.19） points vs （3.66±0.86） points, P＜0.05］, and the VAS score of the observation group was significantly lower than that of the control group at 1 month after treatment （P＜0.05）. The Quinnell grade of the observation group was better than that of the control group immediately after treatment and 1 month after treatment （P＜0.05）. One month after treatment, the total effective rate was 100% in the observation group and 79.31% in the control group. The thickness of tendon in the observation group was （3.60±0.30） mm and that in the control group was （3.78±0.32） mm. There was significant difference between the two groups （P＜0.05）. Conclusion Ultrasound-guided compound betamethasone injection combined with needle knife release in the treatment of stenotic tenosynovitis of thumb flexor tendon has high effective rate, early recovery of affected finger activity, and the clinical effect is better than that of drug injection alone.