Abstract:Objective To observe the clinical effect of Yiqi Huoxue Tongmai decoction combined with western medicine on stable angina pectoris(SAP) with Qi deficiency and blood stasis. Methods A total of 82 inpatients with SAP of Qi-deficiency and blood-stasis type in Nanjing Hospital of Chinese Medicine from July 2020 to June 2021 were randomly divided into treatment group and control group (n=41, each). The conventional western medicine was given in control group, and Yiqi Huoxue Tongmai decoction was added on the basis of conventional drugs in treatment group. The treatment course for both groups was 4 weeks.The traditional Chinese medicine(TCM) syndrome efficacy, angina pectoris attack, Seattle angina pectoris scale (SAQ), Pittsburgh sleep quality index score (PSQI), echocardiographic indexes of cardiac function［left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD)］ and 6-minute walking test (6MWT) were observed before and after treatment and compared between two groups. Results After 4 weeks of treatment, the curative effect of TCM syndrome in treatment group was better than that in control group (92.68% vs 73.17%, P<0.05). After the treatment,the frequency and duration of angina pectoris attack, nitroglycerin dosage and PSQI score significantly decreased in both groups, and they were lower in treatment group than those in control group(P＜0.01). SAQ score increased after treatment in both groups and was higher in treatment group than that in control group (P<0.01). LVEF and 6MWT increased, and LVEDD and LVESD decreased in two groups after treatment (P<0.05), and 6MWT in treatment group was higher than that in control group (P<0.05). Conclusion Yiqi Huoxue Tongmai decoction combined with western medicine based on psycho-cardiology is conducive to reduce symptoms and improve exercise endurance, the quality of life and sleep in the patients with SAP of Qi-deficiency and blood-stasis type.