Abstract:Objective To explore the effect of enhanced recovery after surgery (ERAS) in the perioperative period of splenectomy combined with pericardial devascularization in elderly patients with portal hypertension. Methods A retrospective analysis was performed on the clinical data of 62 elderly patients over 65 years old received splenectomy combined with pericardial devascularization due to cirrhotic portal hypertension Huai'an First People's Hospital from August 2015 to August 2019. There were 32 patients treated with ERAS during perioperative period (ERAS group) and 30 patients with traditional practice during perioperative period (control group). Intraoperative conditions, incidence of postoperative complications, hospital stay and hospitalization costs were compared between two groups. Results There was no significant difference in intraoperative bleeding, operation time, cardiovascular events, bleeding, infection, liver dysfunction, incidence of portal vein thrombosis, postoperative death and 30-day readmission rate between two groups (P>0.05). However, the electrolyte disturbance rate, the overall complication rate, postoperative pain score, the postoperative hospital stays and the hospitalization cost were lower in ERAS group compared with those in control group(P<0.05，P＜0.0１). Conclusions For the elderly patients received splenectomy combined with pericardial devascularization, ERAS during the perioperative period can improve patient comfort, and shorten the length and the cost of hospital stay.