Abstract:Objective To analyze the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and Behcet's disease(BD) activity, to further explore its possibility as a potential marker for evaluating disease activity in BD. Methods Forty-three BD inpatients in the Qinghai University Affiliated Hospital from January 2019 to December 2020 were selected as case group, and 43 healthy persons were served as control group. The patients in case group was divided into high-activity group and low-activity group according to electronic medical record-based disease activity index (EMRAI). The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and MHR level were compared between two groups, the associations of MHR with CRP and ESR was analyzed. The judgment efficiency of MHR on BD activity was analyzed by drawing receiver operating characteristics (ROC) curve. Results The levels of CRP, ESR and MHR in case group were significantly higher than those in control group (P<0.01), and MHR in high-activity group was higher than that in low-activity group［（0.64±0.28）×10⁹/mmol vs （0.36±0.20）×10⁹/mmol，P<0.01］. Spearman correlation analysis showed that MHR was positively correlated with EMRAI, ESR and CRP respectively (r=0.504, 0.311,0.555,P<0.01). ROC analysis showed that the optimal critical value of MHR in distinguishing between low disease activity and high disease activity in BD patients was 0.317×10⁹/mmol, and the area under ROC was 0.798 ［95%CI(0.660-0.941), P<0.01］ . Conclusion MHR is positively correlated with EMRAI and has a higher judgment efficiency on disease activity in BD patients, suggesting that it may be used as a biomarker for the evaluation of Behcet's disease activity.