Abstract:ObjectiveTo explore the value of acupoint tenderness response in the diagnosis of renal damage in children with Henoch Schonlein purpura （HSP）. Methods A total of 129 children with HSP treated in the Affiliated Hospital of Shandong University of TCM from October 2019 to April 2021 were selected and divided into observation group (with renal damage, n=64) and control group(without renal damage,n=65). The acupoint tenderness responses of Taixi, Sanyinjiao, Zusanli and Xuehai were evaluated with visual analog scale (VAS) and pressure pain threshold (PPT) in all children. The 24 h urinary protein content and the time for urinary protein disappearance were measured in observation group, and the associations of acupoints tenderness respone with the time of urinary protein disappearance and 24 h urinary protein were analyzed. Results In observation group, VAS scores were significantly higher than those in control group (P<0.01,P<0.05), and PPTs were lower than those in control group (P<0.01,P<0.05). There were no correlations between the time for urinary protein disappearance and the VAS score and PPTs at the four acupoints (P>0.05). In observation group, VAS score of tenderness at Taixi acupoint was positively correlated with the 24 hour urinary protein content (P<0.05), and also PPT at Taixi acupoint was negatively correlated with 24 hour urine protein content(P<0.05), but the VAS score of tenderness and PPT at other acpoints were not correlated with 24 h urinary protein content（P>0.05）. Conclusions The tenderness response of Taixi, Sanyinjiao, Zusanli and Xuehai points may reflect whether there is renal damage in children with HSP, and tenderness at Taixi acupoint can reflect the degree of renal damage at the same time. However, the four acupoints could not predict the duration of the disease.