Abstract:Objective To investigate the clinical effect of total abdominal fascial compartment resection on the treatment of primary retroperitoneal liposarcoma(PRPLS). Methods A total of 107 patients with PRPLS treated from May 1990 to April 2018 in the General Hospital of Angang Group were enrolled. The surgical treatment measures,postoperative pathology and recurrence were compared between two groups.All patients were followed up after operation to analyze the factors affecting postoperative recurrence. Results The recurrence rate was 21.50%(23/107).Univariate analysis showed that there were significant differences in the recurrence rate of patients with different tissue types and with whether the patients underwent nephrectomy,intestinal or mesenteric resection,partial pancreatectomy and splenectomy (P<0.05,P<0.01). The total incidence of complications in research group was significantly higher than that in control group(64.58% vs 15.25%, χ²=27.514,P<0.01). Conclusion Total abdominal fascial compartment resection can effectively prevent the recurrence of PRPLS, but the incidence of post-operative complications is relatively high because of long-time operation,wide resection range and difficult operative procedures.