Abstract:Objective To compare the efficacy and safety of endoscopic submucosal excavation (ESE) and endoscopic full-thickness resection (EFTR) in the treatment of gastric stromal tumour (GST). Methods The clinical data of patients received ESE (n=60) or EFTR (n=53) for GST in Zhongda Hospital Jiangbei Branch from January 2016 to June 2020 were collected to compare the operative conditions and safety of two different methods. Results The operation time ［(57.1±25.1) min vs (72.4±20.0) min］, hospitalization time ［(8.3±2.5) d vs (10.5±3.5) d］ and the hospitalization expenses ［(27 418.3±5 520.8) yuan vs (30 147.8±4 819.5) yuan］ in ESE group were significantly lower than those in EFTR group（P＜0.01）.The postoperative leukocyte count was significantly higher than that before operation in two groups (P<0.01), but there was no significant difference in it between two groups (P>0.05). There were 98 patients followed up for (25.07±12.09) months, without the recurrence of GST. The total satisfaction rate of patients was 98.0% (96/98). Conclusion Endoscopic treatment of GST is reliable and safe. Compared with EFTR, ESE can obviously reduce the operation time, hospital stay and hospitalization expenses for the patients.