Abstract:Objective To explore the feasibility and clinical effect of different methods in repairing skin and soft tissue defects.Methods Sixty cases of skin and soft tissue defects caused by different causes treated from February 2017 to December 2020 were selected and randomly divided into experimental group and control group (n=30,each). In experimental group, the patients underwent heterogeneous acellular dermis matrix (HADM) and autologous blade thick skin combined with vacuum sealing drainage (VSD) to repair skin and soft tissue defects. In control group, split-thickness skin graft combined with VSD was conducted to repair skin and soft tissue defects. The skin graft survival rate, operation times, hospital stay, bacterial culture of blood and secretions were observed and compared between two groups. Vancouver Scar Scale (VSS) was used to evaluate the scar tissue formation at 6 months after operation. Results The survival rate of skin graft in experimental group was significantly higher than that in control group ［(92.0 ±7.0)% vs(86.8±9.0)%, P＜0.05］. The number of operations, hospital stay and VSS score at 6 months after operation in experimental group were statistically lower than those in control group (P<0.05). The positive rates of blood and secretions bacterial culture in experimental group were significantly lower than those in control group (P<0.05). Conclusion For repairing skin and soft tissue defects, HADM and autologous blade thick skin combined with VSD has good clinical effect, with lighter healing scar and excellent outcome for repairing.