Abstract:Objective To explore the predictive value of 12-zone lung ultrasound score method in the treatment of neonatal respiratory distress syndrome (NRDS) with mechanical ventilation to provide a basis for clinical treatment. Methods A total of 580 children diagnosed with NRDS in Guangdong Second Provincial General Hospital from April 2018 to May 2019 were selected as the research subjects. Within 2 hours after the first chest X-ray examination, 12-zone lung ultrasound score was finished, and different auxiliary ventilation methods were performed according to the severity of the disease. Spearman correlation was used to analyze the associations of pulmonary ultrasound score with X-ray classification and auxiliary ventilation mode. ROC curve was drawn to pre-evaluate the predictive efficacy of 12-zone lung ultrasound score method in mechanical ventilation of children with NRDS. Results With the increases of X-ray grading and the upgrade of auxiliary ventilation mode, 12-zone lung ultrasound scores increased respectively, the difference was statistically significant （P<0.01，P<0.05）. Spearman correlation analysis showed that there were positive correlations between pulmonary ultrasound 12 zone score and X-ray grade (r=0.692, P<0.01) and between auxiliary ventilation modes and X-ray grade (r=0.724, P<0.01). For the predictive efficacy of 12-zone lung ultrasound scoring method, the area under the ROC curve (AUC) was 0.867, with predictive sensitivity of 0.871 and specificity of 0.637, when the critical value was 12.76.Conclusions Lung ultrasound using 12-zone method can be used to predict the application of mechanical ventilation in children with NRDS. There is a certain correlation between 12-zone lung ultrasound scoring and X-ray classification.