Abstract:Objective To investigate the clinical significance of insulin-like growth factor 1 (IGF-1), retinol binding protein (RBP) and cholinesterase (CHE) in the diagnosis of liver cirrhosis. Methods A retrospective analysis was performed on the clinical data of 111 patients with viral hepatitis related liver cirrhosis admitted to Yanan University Affiliated Hospital of from October 2018 to October 2020(cirrhosis group). In the same period, 34 patients of viral hepatitis without cirrhosis were selected as hepatitis group, and 55 healthy subjects were served as control group. IGF-1 was measured by chemiluminescence, RBP and CHE were determined by automatic biochemical analyzer. The levels of IGF-1, RBP and CHE were compared among three groups to analyze their diagnostic efficacy in liver cirrhosis. Results The levels of IGF-1, RBP and CHE in cirrhosis group were significantly lower than those in hepatitis group and control group (P<0.05), and decreased with the increase of Child-Pugh grades, there was a significant difference between Child-Pugh grade A and Child-Pugh grade B and C (P<0.01), and there ws no statistically significant difference between Child-Pugh grade B group and C group (P>0.05). The positive rates of RBP and CHE increased statistically with the increase of Child-Pugh grade (P<0.01). IGF-1, RBP and CHE levels were negatively correlated with Child-Pugh grading (r=-0.297, -0.396, -0.609, P<0.01). The area under ROC of IGF-1, CHE, and RBP was 0.947, 0.915, 0.838, respectively, and the cut-off points were 96.9 ng/ml, 4 707.0 u/L and 19.8 mg/L, respectively. AUC of combined detection of IGF-1, RBP and CHE was respectively higher than those of single indicator. Conclusion IGF-1, RBP and CHE can well evaluate the liver function of liver cirrhosis, and there is a significant correlation among the three indicators, which has a certain clinical significance in predicting liver cirrhosis.