Abstract:Objective To investigate the therapeutic effect, safety, feasibility and advantages of subxiphoid uni-portal thoracoscopic thymectomy. Methods A retrospective analysis was performed on 77 patients receiving subxiphoid uni-portal thoracoscopic thymectomy from September 2018 to May 2020. The incision was located about 1 cm below the xiphoid process with a length of 3 cm, and the single sternum retractor was applied during the operation. After operation,expectorant and analgesic measures were taken in all patients. Results The subxiphoid single-port thoracoscopic total thymectomy under general anesthesia were successfully completed in 77 cases. Postoperative pathology confirmed 65 cases of malignant tumors (64 cases of thymoma and 1 case of thymic cancer) and 12 cases of benign diseases (5 cases of thymic cyst, 2 cases of bronchial cyst and 5 cases of thymic hyperplasia). Postoperative complications included 2 cases of atrial fibrillation and 4 cases of small amount of pleural effusion, and the symptoms were improved after treatment. No serious complications such as phrenic nerve paralysis, laryngeal nerve damage and chylothorax occurred. No myasthenia gravis crisis occurred within 30 days after operation in 6 patients complicated with myasthenia gravis before operation. There was no death within 30 days after operation. Conclusion Transxiphoid single hole approach can achieve total thymectomy with less trauma and rapid postoperative recovery.