Abstract:Objective To study the effects of different anesthesia and analgesia Methods on serum basic fibroblast growth factor(bFGF) in patients with tibial fracture. Methods Eighty patients with tibial fracture operated from February 2019 to February 2020 in Second Hospital of Shanxi Medical University were selected and divided into general anesthesia group and spinal-epidural anesthesia group( n =40, each). The levels of bFGF in peripheral venous blood were measured before anesthesia (T0), immediately after operation (T1), 24 hours (T2) and 72 hours (T3) after operation, and the changes of vital signs and adverse reactions were simultaneously observed. The heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), serum bFGF levels at T0~T3 and postoperative visual analogue scale (VAS) scores were analyzed and compared between two groups. Results At T1, T2 and T3, serum bFGF level in spinal-epidural anesthesia group was significantly higher than those in general anesthesia group ( P <0.05). The serum bFGF level showed the trend of first decrease and then increase at each time point in two groups and increased statistically in spinal-epidural anesthesia compared with general anesthesia group ( P <0.01). The serum bFGF level at T0, T2 and T3 was significantly higher than that at T1 in two groups（ P <0.05）. At 2 hours after operation, VAS score in spinal-epidural anesthesia group was statistically lower than that in general anesthesia group ( P <0.01).There was significant difference in the physical condition between two groups during postoperative follow-up period ( P <0.05) . Conclusion Compared with general anesthesia, intraspinal anesthesia and epidural analgesia can provide superior postoperative analgesia for patients undergoing tibial fracture surgery, and can increase serum bFGF level in the early postoperative period, which is conducive to the recovery of the patients.