Abstract:Objective To investigate the therapeutic effects of treatment options for primary immune thrombocytopenia (ITP) at different stages. Methods In 246 ITP patients who received glucocorticoid as initial treatment at Nanjing Jiangbei Hospital from June 2014 to February 2020,the effective rate of initial with glucocorticoid treatment and the effective rates of re-use hormone therapy and splenectomy for patients with ineffective initial glucocorticoid and recurrent ITP were retrospectively analyzed. The clinical effect of different treatment for chronic ITP was compared.Results The effective rates were 65.0% (160/246)for ITP patients with complete response and without recurrence,58.3% (28/48) for patients re-using hormone therapy because of ineffective initial glucocorticoid or recurrent ITP and 87.5% (7/8) for patients re-treated with splenectomy.In the treatment of chronic ITP,platelet count in the low-dose hormone combined with azathioprine group was slightly higher than that in the single low-dose hormone group,but the difference between them was not significant(P>0.05).Conclusion Hormone therapy is the first choice for treatment of newly diagnosed adult ITP patients.Both splenectomy and hormone therapy have reliable and good effects in the patients with ineffective initial glucocorticoid and recurrent ITP.Low-dose of hormone combined with azathioprine has a better effect than low- dose hormone alone in the treatment of chronic ITP.