Abstract:Objective To analyze and summarize the clinical characteristics, diagnosis and treatment of IgG4-related abdominal disease, and improve the level of diagnosis and treatment of IgG4-related abdominal disease. Methods The clinical data of 31 patients with IgG4-related abdominal disease in Tongji Hospital from January 2010 to September 2020 were analyzed retrospectively. Results Among the 31 patients with IgG4-related abdominal disease, there were 27 males (87.10%) and 4 females (12.90%), aged (67.26 ± 6.16) years. The clinical manifestations were abdominal pain and discomfort (21 cases, 67.74%), jaundice and abnormal liver function (4 cases, 12.90%), abnormal renal function (4 cases, 12.9%), low back pain (1 case, 3.23%), and retroperitoneal mass (1 case, 3.23%). In the diagnosis, there were 21 cases of IgG4 related autoimmune pancreatitis (67.74%), 4 cases of IgG4 related sclerosing cholangitis (12.90%), 4 cases of IgG4 related nephropathy (12.90%), and 2 cases of IgG4 related retroperitoneal fibrosis (6.45%). A total of 25 patients received glucocorticoid treatment, among them there were 3 patients relapsed after drug withdrawal and they were treated with prednisone acetate or combined with immunosuppressant again and the symptoms improved and the level of IgG4 decreased in reexamination. There were 6 patients received surgical treatment, and none died. Conclusion IgG4-related abdominal disease is rare, and the clinical understanding is generally insufficient. Abdominal lesions were mainly IgG4 related autoimmune pancreatitis with characteristic imaging findings. Glucocorticoid is effective, but there is a risk of recurrence after discontinuation.