Abstract:Objective To explore the effect of alprostadil combined with cilostazol and mupirocin in the treatment of elderly patients with diabetic foot.Methods Out of 64 elderly patients with diabetic feet hospitalized between January 2012 and January 2020,51 patients meeting inclusion and exclusion criteria were selected and retrospectively studied.The patients were categorized as exposed group (n=20) and non-exposed group (n=31).Cilostazol and mupirocin were used on the basis of alprostadil in exposed group,while alprostadil alone was used in non-exposed group.The clinical indexes,treatment duration and total effective rate were compared between two groups.Results The baseline level of urinary micro albumin-to-creatinine ratio (UACR) in exposed group was significantly higher than that in non-exposed group ［71.00 (43.50,172.83) mg/g vs 48.90 (31.50,60.00) mg/g,P< 0.05］.The incidence of unpalpable dorsalis pedis artery pulse in non- exposed group was slightly higher than that in exposed group (P>0.05).There was no significant difference in treatment duration between exposed group and non -exposed group ［(10.71±3.79)d vs (12.60±4.72)d,P>0.05).The total effective rate in exposed group was significant higher than that in non-exposed group (90.00% vs 64.52%,P<0.05).No obvious adverse drug reactions occurred in both groups.conclusions The total effective rate of combined drug treatment is higher,with a shorter treatment duration,which may be related to its mechanism being more targeted at the pathogenesis of diabetic foot.