Abstract:Objective To investigate the safety and effectiveness of simultaneous treatment by laparoscopy,choledochoscopy and duodenoscopy for cholecystolithiasis combined with choledocholithiasis.Methods A retrospective analysis was performed on the clinical data of 60 patients with cholecystolithiasis and choledocholithiasis admitted to Nanjing Drum Tower Hospital from October 2017 to October 2020.The patients treated with endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic cholecystectomy (LC) were selected as control group (n=26),and the patients received combination operation of laparoscopy,choledochoscopy and duodenoscopy were selected as experimental group (n=34).The operation-related indexes and prognostic related indicators were compared and analyzed between two groups.Results All patients were successfully operated under minimally invasive surgery.The operation time ［(165.0±53.3) min vs (203.1±60.3) min］,postoperative hospital stay ［(7.7±2.8) d vs (9.8±4.3)d］ and total hospital expenses ［(31 616±5 175) yuan vs (35 748±6 924) yuan］ in experimental group were significantly lower than those in control group (P<0.05).No obvious residual stones were found by cholangiography before discharge in both groups,and the incidence of postoperative complications in experimental group was significantly lower than that in control group (2.9% vs 23.1%,χ²=4.007,P<0.05).conclusions In the treatment of cholecystolithiasis with choledocholithiasis,combined application of laparoscopy,choledochoscopy and duodenoscopy (three endoscopies) is safe and effective.