Abstract:Objective To explore the relationship between thyroid-stimulating hormone (TSH) and risk factors for ischemic cerebrovascular disease (ISC) in the patients with subclinical hypothyroidism (SCH). Methods A total of 61 ISC patients complicated with SCH treated from September 2018 to September 2020 were selected and divided into in group A (4.20 μIU/ml≤TSH<10 μIU/ml,n=21) and group B(TSH≥10 μIU/ml,n=40)according to serum TSH level.In the same period,34 healthy people were served as control group.Serum levels of TSH,free thyroid hormone (FT₄),total cholesterol (TG),triglyceride (TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),homocysteine (Hcy) and carotid artery intima-media thickness (CIMT) were detected and analyzed in three groups. Results FT₄ level was the lowest in group B,followed by group A and control group,but there was no significant difference in it among three groups(P>0.05).The CIMT of SCH patients in group A and B was slightly higher than that in healthy control group,but the difference was not significant(P>0.05).The levels of TSH,TC,TG,LDL-C and Hcy in group B were significantly higher than those in group A and control group,and the levels of TSH,LDL-C and Hcy in group A were statistically higher than those in control group (P<0.01).TSH was positively correlated with TG,TC,LDL-C and Hcy,respectively(r=0.332,0.662,0.680,0.665,P＜0.01). Conclusion SCH patients are more likely to suffer from ISC and the higher the TSH level,the greater the risk of ISC.