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投稿时间：2020-08-31 网络发布日期：2021-06-20
投稿时间：2020-08-31 网络发布日期：2021-06-20
中文摘要: 目的 分析白血病骨髓移植患者治疗期间营养状况及影响因素,为临床干预提供参考。方法 回顾性分析2018年1月至2019年12月新华医院收治的84例急性髓系白血病(AML)患者的临床资料。检测白蛋白水平评估AML患者治疗期间的营养状况;统计患者一般资料,包括性别、年龄、BMI、居住地、焦虑情况、预处理方式、营养支持方式、供体来源等。结果 84例AML患者骨髓移植治疗期间,36例发生营养不良,发生率为42.86%;经多因素分析结果显示,焦虑、X射线全身照射(TBI)联合环磷酰胺(CY)、肠外营养是白血病骨髓移植治疗患者发生营养不良的独立危险因素(P<0.01)。结论 伴有焦虑心理、预处理方式为TBI联合CY、接受肠外营养支持的AML患者,在骨髓移植治疗期间发生营养不良的风险较高,临床应据此采取合理的干预,以降低营养不良的发生。
Abstract:Objective To analyze the nutritional status and influencing factors of leukemia patients received bone marrow transplantation (BMT). Methods The clinical data of 84 patients with acute myeloid leukemia (AML) treated from January 2018 to December 2019 were retrospectively analyzed. The nutritional status of AML patients during treatment was evaluated by the level of albumin, and the general information was collected, including patients′ gender, age, BMI, place of residence, anxiety, pretreatment methods, nutritional support, and donor sources. Results Of 84 AML patients, there were 36 cases of malnutrition(42. 86%). Multi-factor analysis showed that anxiety, total body irradiation (TBI) combined with cyclophosphamide (CY) and parenteral nutrition were the independent influencing factors of malnutrition in AML patients (P<0.01). Conclusion AML patients with anxiety, TBI combined with CY for pretreatment and parenteral nutrition support have higher risk of malnutrition during BMT treatment, and reasonable interventions should be taken to reduce the incidence of malnutrition in clinic.
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| Author Name | Affiliation |
| WU Ya-wen, ZOU Tian-yun | Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China |
引用文本：
吴雅雯,邹天韵.白血病骨髓移植患者治疗期间营养状况及影响因素[J].中国临床研究,2021,34(6):799-801.
吴雅雯,邹天韵.白血病骨髓移植患者治疗期间营养状况及影响因素[J].中国临床研究,2021,34(6):799-801.