Abstract:Objective To investigate the expression of microRNA-150 (miR-150) in gastric cancer tissue and its prognostic value.Methods A total of 108 patients who were diagnosed as gastric cancer by pathology from January 2008 to December 2010 in Drum Tower Hospital were selected as research objects.RT-PCR was used to detect the expression of miR-150 of gastric cancer tissues and para-cancerous tissue.Chi-square test was used to detect and analyze the correlation between the expression level of miR-150 and clinicopathological features.The prognostic value was analyzed by Kaplan-Meier estimator and Cox regression.Results The relative expression of miR-150 in gastric cancer tissue was higher than that of its para-cancerous tissues (P<0.01).The expression of miR-150 was closely related to tumor invasion depth,TNM stage,lymph node metastasis and distant metastasis (P<0.05),but not with gender,age,tumor location,tumor size and differentiation (P>0.05).Kaplan-Meier survival analysis showed that the overall survival rate of patients with low expression of miR-150 was significantly higher than that of patients with high expression of miR-150 (P<0.01).Cox regression analysis showed that age≥60 years old (HR=1.946，95%CI：1.269-2.984，P=0.002),lymph node metastasis (HR=2.412，95%CI：1.094-5.319，P=0.029) and high expression of miR-150(HR=1.869,95% CI:1.185-2.949,P=0.007) were independent risk factors for the prognosis of gastric cancer.Conclusion The high expression of miR-150 may suggest that the bad prognosis of gastric cancer patients,and miR-150 could become a new biomarker to predict the prognosis of gastric cancer.